Gene information
Official symbol ITGB3
Official full name integrin subunit beta 3
Gene type protein-coding gene
Chromosome17q21.32
Alias symbolCD61; GPIIIa
Previous symbolGP3A
Gene familyCD molecules; Integrin beta subunits
Resources
Entrez Gene 3690
HGNC HGNC:6156
Ensembl ENSG00000259207
Vega OTTHUMG00000171956
UCSC uc002ilj.4
GO terms: 90 records
GO Description Category LogP Number of genes Detail
GO:0001505 regulation of neurotransmitter levels GO Biological Processes -3.63969141 10 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001618 virus receptor activity GO Molecular Functions -7.88412825 17 More
GO:0001704 formation of primary germ layer GO Biological Processes -8.70692533 22 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002090 regulation of receptor internalization GO Biological Processes -5.25557829 7 More
GO:0005172 vascular endothelial growth factor receptor binding GO Molecular Functions -3.72261873 5 More
GO:0005520 insulin-like growth factor binding GO Molecular Functions -5.13373504 7 More
GO:0005902 microvillus GO Cellular Components -2.78324946 11 More
GO:0005911 cell-cell junction GO Cellular Components -3.41801827 38 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0007229 integrin-mediated signaling pathway GO Biological Processes -5.80936917 16 More
GO:0007369 gastrulation GO Biological Processes -9.78060849 28 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010743 regulation of macrophage derived foam cell differentiation GO Biological Processes -20.3455172 15 More
GO:0010745 negative regulation of macrophage derived foam cell differentiation GO Biological Processes -12.3554756 8 More
GO:0010883 regulation of lipid storage GO Biological Processes -22.5241589 19 More
GO:0010888 negative regulation of lipid storage GO Biological Processes -13.5596033 10 More
GO:0015026 coreceptor activity GO Molecular Functions -2.48314997 7 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0016853 isomerase activity GO Molecular Functions -1.41249432 5 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019956 chemokine binding GO Molecular Functions -7.24411974 11 More
GO:0030027 lamellipodium GO Cellular Components -1.61995196 15 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030100 regulation of endocytosis GO Biological Processes -14.0757782 22 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030667 secretory granule membrane GO Cellular Components -8.32957622 38 More
GO:0031092 platelet alpha granule membrane GO Cellular Components -5.90191637 5 More
GO:0031252 cell leading edge GO Cellular Components -1.97716247 28 More
GO:0031253 cell projection membrane GO Cellular Components -3.08510132 12 More
GO:0031589 cell-substrate adhesion GO Biological Processes -10.7590108 32 More
GO:0031994 insulin-like growth factor I binding GO Molecular Functions -5.14025860 6 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032369 negative regulation of lipid transport GO Biological Processes -16.5715041 21 More
GO:0033627 cell adhesion mediated by integrin GO Biological Processes -3.57905448 8 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034103 regulation of tissue remodeling GO Biological Processes -21.5631413 32 More
GO:0034446 substrate adhesion-dependent cell spreading GO Biological Processes -3.29518609 9 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043277 apoptotic cell clearance GO Biological Processes -6.75865733 12 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044409 entry into host GO Biological Processes -10.3666963 14 More
GO:0045211 postsynaptic membrane GO Cellular Components -5.83105498 30 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045806 negative regulation of endocytosis GO Biological Processes -6.50553130 8 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0046718 viral entry into host cell GO Biological Processes -10.4786216 14 More
GO:0046850 regulation of bone remodeling GO Biological Processes -7.11509809 13 More
GO:0048259 regulation of receptor-mediated endocytosis GO Biological Processes -11.3903749 15 More
GO:0048261 negative regulation of receptor-mediated endocytosis GO Biological Processes -5.41560423 6 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050919 negative chemotaxis GO Biological Processes -2.66946679 4 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051580 regulation of neurotransmitter uptake GO Biological Processes -3.00303064 3 More
GO:0051588 regulation of neurotransmitter transport GO Biological Processes -2.92721908 6 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0090287 regulation of cellular response to growth factor stimulus GO Biological Processes -21.1381780 60 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:0098636 protein complex involved in cell adhesion GO Cellular Components -5.90313372 12 More
GO:0098794 postsynapse GO Cellular Components -5.82876983 23 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098802 plasma membrane signaling receptor complex GO Cellular Components -6.47096721 17 More
GO:0098858 actin-based cell projection GO Cellular Components -2.23189213 18 More
GO:0098978 glutamatergic synapse GO Cellular Components -4.83590061 31 More
GO:0140272 exogenous protein binding GO Molecular Functions -8.63789613 18 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905953 negative regulation of lipid localization GO Biological Processes -25.1573575 31 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 11 records
KEGG Description Category LogP Number of genes Detail
hsa04145 Phagosome KEGG Pathway -11.4012504 17 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04380 Osteoclast differentiation KEGG Pathway -7.05199617 21 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa04512 ECM-receptor interaction KEGG Pathway -16.8587083 28 More
hsa04611 Platelet activation KEGG Pathway -14.0379587 18 More
hsa04613 Neutrophil extracellular trap formation KEGG Pathway -12.8071279 20 More
hsa04919 Thyroid hormone signaling pathway KEGG Pathway -4.89554233 17 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05168 Herpes simplex virus 1 infection KEGG Pathway -3.99478875 17 More
hsa05414 Dilated cardiomyopathy KEGG Pathway -7.04373804 18 More
Drug-Gene interaction
view
Related drugs: 14 records
Drug name Interaction type Source PMID View
abciximab antagonistinhibitorantibody TdgClinicalTrialChemblInteractionsTENDPharmGKB 20938371185104781158853412749745174419041175235212165285 view
abituzumab inhibitor ChemblInteractions view
aspirin PharmGKB 1718464516458133166750001172301616493486107041691105408915840736104599131615393023834376220283522013833416581111 view
cilengitide inhibitorantagonist TALCDTCTdgClinicalTrialChemblInteractions 24095096 view
clopidogrel PharmGKB 151669491910608316458133195303212383437622028352 view
cypate DTC 22871580 view
eptifibatide inhibitor TdgClinicalTrialChemblInteractionsTENDPharmGKB 1236011020938371146176941292873811588534146180721059223515860200 view
etaracizumab antibodyantagonist ChemblInteractions view
gantofiban TdgClinicalTrial view
glpg-0187 TdgClinicalTrial view
intetumumab antagonist TdgClinicalTrialChemblInteractions view
tadocizumab antagonist ChemblInteractions view
tirofiban antagonistinhibitor TdgClinicalTrialTENDPharmGKB 20938371105922352021068911752352 view
tirofiban hydrochloride inhibitor ChemblInteractions view
Related studies: 14 records
Molecular factor Omics type Application Objective MI type Reference
NM_000212.3:c.176T>C genomics myocardial infarction[diagnosis] myocardial infarction Carter AM et al. Circulation. 1998
NM_000212.3:c.176T>C genomics myocardial infarction[diagnosis] myocardial infarction Zotz RB et al. Thromb Haemost. 1998
NM_000212.3:c.176T>C genomics myocardial infarction[diagnosis] myocardial infarction Ardissino D et al. Blood. 1999
NM_000212.3:c.176T>C genomics myocardial infarction[diagnosis] myocardial infarction Tereshchenko SN et al. Ter Arkh. 1999
NM_000212.3:c.176T>C genomics myocardial infarction[diagnosis] myocardial infarction Melus V et al. Bratisl Lek Listy. 1999
NM_000212.3:c.176T>C genomics myocardial infarction[diagnosis] myocardial infarction Benze G et al. Eur Heart J. 2002
NM_000212.3:c.176T>C genomics myocardial infarction[diagnosis] myocardial infarction Demidova DV et al. Dokl Biochem Biophys. 2002
NM_000212.3:c.176T>C genomics myocardial infarction[diagnosis] myocardial infarction Bojesen SE et al. J Am Coll Cardiol. 2003
NM_000212.3:c.176T>C genomics myocardial infarction[diagnosis] myocardial infarction Pchelina SN et al. Kardiologiia. 2007
NM_000212.3:c.176T>C genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Santiago-German D et al. J Thromb Thrombolysis. 2012
NM_000212.3:c.176T>C genomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Rivera-Garcia BE et al. Mol Cell Biochem. 2013
NM_000212.3:c.176T>C genomics acute type 4a myocardial infarction[diagnosis] acute type 4a myocardial infarction Verdoia M et al. Platelets. 2014
NM_000212.3:c.176T>C genomics old myocardial infarction[diagnosis] old myocardial infarction Grove EL et al. J Intern Med. 2004
NM_000212.3:c.176T>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Pegoraro RJet al. Cardiovasc J S Afr. 2005
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